The role of the T-cell mediated immune response to Cytomegalovirus infection in intrauterine transmission.

María Soriano-Ramos,Estrella Esquivel-De la Fuente, Eliseo Albert Vicent,María de la Calle,Fernando Baquero-Artigao,Sara Domínguez-Rodríguez,María Cabanes,Enery Gómez-Montes,Anna Goncé,Marta Valdés-Bango, Mª Carmen Viñuela-Benéitez,Mar Muñoz-Chápuli Gutiérrez,Jesús Saavedra-Lozano,Irene Cuadrado Pérez, Begoña Encinas,Laura Castells Vilella, María de la Serna Martínez,Alfredo Tagarro,Paula Rodríguez-Molino,Estela Giménez Quiles, Diana García Alcázar, Antonio García Burguillo,María Dolores Folgueira,David Navarro,Daniel Blázquez-Gamero

PloS one（2023）

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摘要

In this cohort of pregnant women with a primary CMV infection, no association was found between the presence of a CMV T-cell response at the time of maternal infection and the risk of intrauterine transmission. A detectable CMV viral load in the maternal blood at diagnosis of the primary maternal infection may represent a relevant biomarker associated with fetal transmission.

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关键词

cytomegalovirus infection,immune response,t-cell

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