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Overexpression of miR-148a-3p inhibits extracellular matrix degradation and alleviates IL-1β-induced intervertebral disc degeneration.

Hehuan Lai, Jialin Fan,Yejin Zhang,Bin Pan,Wenzheng Pan,Jiawei Fang,Kainan Ni,Zhenzhong Chen,Shijie Liu,Chao Lou,Dengwei He

Iranian journal of basic medical sciences（2023）

Cited 1|Views8
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Abstract
We proved that miR-148a-3p can attenuate ECM loss and protect NP function by inhibiting matrix-degrading enzymes.
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Key words
Extracellular matrix,Intervertebral disc - microRNAs,Nucleus pulposus,miR-148a-3p
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