Glutamine synthetase expression rescues human dendritic cell survival in a glutamine-deprived environment.

Robert Schoeppe,Nathalie Babl,Sonja-Maria Decking, Gabriele Schönhammer, Andreas Siegmund,Christina Bruss,Katja Dettmer,Peter J Oefner,Linus Frick,Anna Weigert,Jonathan Jantsch,Wolfgang Herr,Michael Rehli,Kathrin Renner,Marina Kreutz

Frontiers in oncology（2023）

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摘要

Our results show that GS supports myeloid cell survival in a glutamine poor environment. Notably, in addition to suppressing proliferation and survival of tumor cells, the blockade of GS also targets immune cells such as DCs and macrophages.

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关键词

dendritic cells,glutamate,glutamine,glutamine synthetase,macrophages

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