Seroreversion to Chlamydia trachomatis Pgp3 Antigen Among Children in a Hyperendemic Region of Amhara, Ethiopia

Christine Tedijanto,Solomon Aragie,Sarah Gwyn,Dionna M. Wittberg,Taye Zeru,Zerihun Tadesse,Ambahun Chernet,Isabel J. B. Thompson,Scott D. Nash,Thomas M. Lietman,Diana L. Martin,Jeremy D. Keenan,Benjamin F. Arnold

The Journal of infectious diseases（2023）

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摘要

Monitoring trachoma transmission with antibody data requires characterization of decay in IgG to Chlamydia trachomatis antigens. In a 3-year longitudinal cohort in a high-transmission setting, we estimated a median IgG half-life of 3 years and a seroreversion rate of 2.5 per 100 person-years (95% confidence interval, 1.6-3.5).Clinical Trials Registration. NCT02754583.

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关键词

Chlamydia trachomatis,trachoma,antibody,IgG,seroepidemiology,Ethiopia

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