Bone marrow mesenchymal stem cells paracrine TGF-β1 to mediate the biological activity of osteoblasts in bone repair.

Xiuzhi Zhang,Guangkuo Wang,Weidan Wang,Chunxiao Ran,Fengyuan Piao,Zhijie Ma,Zhaodong Zhang,Guoshuang Zheng,Fang Cao,Hui Xie,Daping Cui,Chukwuemeka Samuel Okoye,Xiaoming Yu,Ziming Wang,Dewei Zhao

Cytokine（2023）

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摘要

Our findings provide evidence that the biological mechanism of BMSC-produced TGF-β1 promotes bone regeneration and repair, providing a theoretical basis and new directions for the application of BMSC transplantation in the treatment of osteonecrosis and bone injury.

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关键词

BMSCs,Bone regeneration,Osteoblasts,Paracrine,TGF-β1

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