Identification of novel genes for age-at-onset of Alzheimer's disease by combining quantitative and survival trait analyses.

Yi-Ju Li,Karen Nuytemans,Jong Ok La,Rong Jiang,Susan H Slifer,Shuming Sun,Adam Naj,Xiaoyi Raymond Gao,Eden R Martin

Alzheimer's & dementia : the journal of the Alzheimer's Association（2023）

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摘要

Genes that influence AAO of AD are excellent therapeutic targets for delaying onset of AD. Several loci identified include genes with promising functional implications for AD.

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关键词

Alzheimer's disease,age at onset,genetic association,polygenic risk score,quantitative trait,survival model

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