Pharmacokinetics/pharmacodynamics of phage therapy: a major hurdle to clinical translation.

Sue C Nang,Yu-Wei Lin,Aleksandra Petrovic Fabijan,Rachel Y K Chang,Gauri G Rao,Jonathan Iredell,Hak-Kim Chan,Jian Li

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases（2023）

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摘要

Recent progress in phage pharmacology has shown that we are in a far better position now to treat infections with phage therapy than a century ago. However, phage therapy is still in its infancy when compared to antibiotics due to the scarce pharmacological knowledge (e.g. PK/PD). Optimization of phage PK/PD is key for translation of phage therapy in patients.

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关键词

Antimicrobial,Bacteriophage,Pharmacodynamics,Pharmacokinetics,Self-replication

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