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Inhibition of RIPK1 kinase does not affect diabetes development: β-Cells survive RIPK1 activation.

Tatiana Takiishi,Peng Xiao,Marie Franchimont,Eduardo H Gilglioni,Erick N Arroba,Esteban N Gurzov,Mathieu Jm Bertrand,Alessandra K Cardozo

Molecular metabolism（2023）

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Abstract
Our results contrast recent literature showing that most cell types undergo necroptosis following RIPK1 kinase activation. This peculiarity may reflect an adaptation to the inability of F062-cells to proliferate and self-renewal.
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Key words
Apoptosis,Necroptosis,Obesity,RIPK1,Type 1 diabetes
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