Homologous recombination deficiency prediction using low-pass whole genome sequencing in breast cancer

Yang Liu,Yalun Li,Min-Zhe Zhang, Dan Chen, Yang Leng, Juan Wang,Bo-Wei Han,Ji Wang

Cancer Genetics（2023）

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摘要

•HRD test is widely used for administrating PARPi chemotherapy in breast cancer.•Existing methods are either experimentally complicated or commercially expensive.•Low-pass WGS based HRD detection method performs well in breast cancer.•Present an HRD test with high accuracy, ease of operation, and acceptable cost.

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关键词

Homologous recombination repair deficiency,Whole genome sequencing,Copy number variations,Breast cancer

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