Association of blood mercury levels with bone mineral density in adolescents aged 12–19
Environmental Science and Pollution Research(2023)
摘要
Bone mass increases rapidly in adolescence, and achieving higher bone mineral density (BMD) during this period can help prevent osteoporosis. However, the effects of metallic mercury on bone health remain controversial. Previous studies have discussed perimenopausal women and older adults, while the association of blood mercury with BMD in adolescents is yet to be studied. Date was collected from the National Health and Nutrition Examination Survey (NHANES) 2011–2018. Weighted multiple linear regression models were used to explore the association of blood mercury levels with BMD in adolescents, while smooth curve fittings and weighted generalized additive models were used to identify the potential nonlinear association. We found that blood mercury levels were negatively associated with BMD in adolescents, though not significantly, based on the results of statistical analyses of 2818 participants. Additionally, the trend in BMD with changes in blood mercury was different in male and female adolescents. We also found an inverted U -shaped association between blood mercury and BMD in male and Mexican–American adolescents. This suggests that increased blood mercury levels within a range may benefit bone health in male adolescents (inflection point: 5.44 nmol/L) and Mexican–American adolescents (inflection point: 5.49 nmol/L), while higher blood mercury levels may harm bone health. More prospective research is needed to confirm our findings.
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关键词
Adolescents,Blood mercury,Bone health,Bone mineral density,Osteoporosis,US population
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