Dose-dependent effects of PRC2 and HDAC inhibitors on cardiomyocyte hypertrophy induced by phenylephrine.
Current drug targets(2023)
摘要
Our data demonstrate diversified effects of TSA and GSK126 on PE-induced cardiomyocyte hypertrophy, and shed light on epigenetic reprogramming in the pathogenesis of cardiac hypertrophy.
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关键词
HDAC,PRC2,cardiac hypertrophy,epigenetic reprogramming,histone acetylation,histone methylation
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