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Whole-brain radiotherapy associated with structural changes resembling aging as determined by anatomic surface-based deep learning.

Nikhil Rammohan,Alexander Ho,Pierre Besson,Tim J Kruser,S Kathleen Bandt

Neuro-oncology（2023）

Cited 0|Views13
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Abstract
Our findings suggest that WBRT causes the brain and its substructures to undergo structural changes at a pace up to 13x of the normal aging pace, where hippocampal avoidance offers focal structural protection. Correlating these structural imaging changes with neurocognitive outcomes following WBRT or HA-WBRT would benefit from future analysis.
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Key words
MRI,aging,brain metastases,deep learning
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