Diagnostic Value of Metagenomic Next-Generation Sequencing for Multi-Pathogenic Pneumonia in HIV-Infected Patients.

Yirui Xie,Bohao Dai,Xiaotang Zhou, Huiting Liu,Wei Wu,Fei Yu,Biao Zhu

Infection and drug resistance（2023）

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摘要

mNGS improved the pathogens detection rate and exhibited advantages in identifying multi-pathogenic pneumonia in HIV-infected patients. Early performance of bronchoscopy and mNGS are recommended in HIV-infected patients with low CD4 T cell counts and long duration of symptoms. The most common pattern of mixed infection observed was fungi-virus, followed by fungi-virus-bacteria coinfection in HIV infected patients with multi-pathogenic pneumonia.

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关键词

HIV,bronchoalveolar lavage fluid,conventional microbiological tests,metagenomic next-generation sequencing,multi-pathogenic pneumonia

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