Amyloid beta accumulations and enhanced neuronal differentiation in cerebral organoids of Dutch-type cerebral amyloid angiopathy patients.

Elena Daoutsali,Barry A Pepers,Stavros Stamatakis,Linda M van der Graaf,Gisela M Terwindt,David A Parfitt,Ronald A M Buijsen,Willeke M C van Roon-Mom

Frontiers in aging neuroscience（2022）

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摘要

These results illustrate the potential of cerebral organoids as in vitro disease model of D-CAA that can be used to understand disease mechanisms of D-CAA and can serve as therapeutic intervention platform for various Aβ-related disorders.

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关键词

Aβ accumulations,Dutch-type cerebral amyloid angiopathy,astrocytes,cerebral organoids,in vitro 3D disease modeling

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