Piceatannol promotes neuroprotection by inducing mitophagy and mitobiogenesis in the experimental diabetic peripheral neuropathy and hyperglycemia-induced neurotoxicity

•.•PCN alleviated hyperglycemia-induced neurotoxicity, as reflected by an improvement in neuritogenesis.•Treatment with PCN increases paw withdrawal threshold and tail-flick latencies in diabetic animals which indicates its ability to relieve from sensory, and functional disturbances associated with diabetic neuropathy.•Treatment with PCN a SIRT-1 and Nrf2 activator also regulates the mitochondrial quality control by enhancing PGAM5 and PARL which may contribute to mitochondrial function in experimental diabetic neuropathy.•PCN increases mitobiogenesis and mitophagy via the SIRT1- PGC-1α-NRF2-TFAM & SIRT1-PINK1-Parkin axis.•PCN provides neuroprotection in experimental DN by inducing mitochondrial biogenesis and turnover.