Pharmacokinetics and pharmacodynamics of intramuscular dexmedetomidine in dogs.

Turi K Aarnes, Brian T Dent,Jeffrey Lakritz,Butch KuKanich,Vincent A Wavreille,Phillip Lerche,Carolina H Ricco Pereira,Richard M Bednarski

American journal of veterinary research（2023）

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摘要

Variations in plasma concentrations occurred in all dogs for the 2 hours postinjection of dexmedetomidine at 10 µg/kg, IM. This was likely due to alterations in absorption due to dexmedetomidine-induced local vasoconstriction. Despite variable plasma concentrations, all dogs were sedated following IM dexmedetomidine administration.

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关键词

intramuscular dexmedetomidine,pharmacokinetics,pharmacodynamics

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