Quantifying trial-by-trial variability during cortico-cortical evoked potential mapping of epileptogenic tissue.
Epilepsia(2023)
Abstract
These findings suggest that standard approaches for CCEP mapping, which involve computing a trial-averaged response over a .2-1 Hz stimulation train, may be masking inter-trial variability that localizes to epileptogenic tissue. We also found that CCEP N1 amplitudes synchronize with ongoing low-frequency oscillations in the hippocampus. Further targeted experiments are needed to determine whether phase-locked stimulation could have a role in localizing epileptogenic tissue.
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Key words
Cortico-cortical evoked potentials,Epilepsy,Epileptic spikes,Hippocampal theta,Seizure,onset zone
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