Evaluation of 28-day estradiol and progesterone vaginal rings in a phase 1 clinical pharmacokinetic study.

Louise Hull,Bronwyn G A Stuckey, Kimberly Hartman,Nadene Zack,David R Friend

Menopause (New York, N.Y.)（2023）

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摘要

The 80/4 IVR and 160/8 IVR gave similar steady-state concentrations of E2 as seen with drug products approved by the US Food and Drug Administration for treatment of VMS and genitourinary symptoms of menopause. The E2 concentrations of this study support the potential of DARE-HRT1, a promising new option for hormone therapy for treatment of VMS and vaginal symptoms associated with menopause.

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关键词

progesterone,vaginal rings,estradiol,clinical pharmacokinetic study

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