Macrophage Galactose Lectin Contributes to the Regulation of FVIII (Factor VIII) Clearance in Mice-Brief Report.

Soracha E Ward,Thomas Guest,Ciara Byrne,Patricia Lopes,Jamie M O'Sullivan,Dearbhla Doherty,David O'Connell, Sara Gutierrez Llaneza,Alain Chion,Judicael Fazavana,Padraic G Fallon,Roger J S Preston,Jill M Johnsen,Steven W Pipe,Peter L Turecek,James S O'Donnell

Arteriosclerosis, thrombosis, and vascular biology（2023）

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摘要

Cumulatively, these findings demonstrate that MGL plays an important role in regulating macrophage-mediated clearance of both VWF-bound FVIII and free-FVIII in vivo. We propose that this novel FVIII clearance pathway may be of particular clinical importance in patients with type 2N or type 3 Von Willebrand disease.

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mechanisms,pathophysiology,physiology,vascular biology

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