A single dose of exercise stimulates skeletal muscle mitochondrial plasticity in myotonic dystrophy type 1.

Andrew I Mikhail,Alexander Manta,Sean Y Ng,Aislin K Osborne,Stephanie R Mattina,Mark R Mackie,Vladimir Ljubicic

Acta physiologica (Oxford, England)（2023）

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摘要

Collectively, our data indicate that mitochondrial dynamics and turnover processes in DM1 skeletal muscle are initiated with a single dose of exercise, which may underlie the adaptive benefits previously documented in DM1 mice and patients.

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关键词

AMP-activated protein kinase,autophagy,biogenesis,dynamics,mitophagy

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