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LUNG PROTECTIVE POTENTIAL EFFECT OF ZILEUTON DURING ENDOTOXAEMIA MODEL IN MALE MICE.

Zainab Ali Alnfakh,Rana Talib Al-Nafakh,Ahmed M Abdul Hameed, Mohamad Abid Abdelhussain,Najah R Hadi

Wiadomosci lekarskie (Warsaw, Poland : 1960)（2022）

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Abstract
Conclusions: The results of the present study revealed that zileuton has the ability to attenuate lung dysfunction during CLP induced polymicrobial sepsis in male mice through their modulating effects on LTB4,12(S) HETE and oxidative stress downstream signaling pathways and subsequently decreased lungtissue levelsof proinflammatory cytokines (IL-1β, and IL-6,IL-17).
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Key words
IL-17 , IL-1B , zileuton , 12(S)HETE , CLP , F2-isoprostane , IL-6 , LTB-4 , endotoxemia,sepsis
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