A two-faced selectivity solution to target SMARCA2 for cancer therapy

Nature communications（2023）

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摘要

Two new studies exploring PROTAC-mediated degradation of SMARCA2 for cancer therapy solve an apparently intractable selectivity challenge with SMARCA4 by utilising the requirement for a productive ternary complex between the protein, PROTAC and ligase complex.

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关键词

smarca2,selectivity solution,cancer,two-faced

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