Scavenger receptor a is a major homeostatic regulator that restrains drug-induced liver injury.

Chunqing Guo,Wenjie Liu,Zheng Liu,Jinyang Cai,Xiaofei Yu,Hongxia Wang,Xia Li,Daming Zuo,Xixian Jiang,Bei Zhang,Jinze Liu,Arun J Sanyal,Puneet Puri,Huiping Zhou,Xiang-Yang Wang

Hepatology (Baltimore, Md.)（2023）

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摘要

We identify a novel hepatocyte-extrinsic pathway governed by the immune receptor SRA that maintains liver homeostasis upon drug insult. Giving that drug (ie, APAP) overdose is the leading cause of acute liver failure, targeting this hepatoprotective SRA-IL-10 axis may provide new opportunities to optimize the current management of drug-induced liver injury.

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关键词

scavenger receptor,liver injury,major homeostatic regulator,drug-induced

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