Randomized Trial of Tenofovir With or Without Peginterferon Alfa Followed by Protocolized Treatment Withdrawal in Adults With Chronic Hepatitis B.

Norah A Terrault,Anna S Lok,Abdus S Wahed,Marc G Ghany,Robert P Perrillo,Michael W Fried,David K Wong,Mandana Khalili,Daryl T Y Lau,Richard K Sterling,Adrian M Di Bisceglie,M Lisker-Melman,Stewart L Cooper, Ray T Chung,Keyur Patel,Lewis R Roberts,Steven H Belle,Harry L A Janssen

The American journal of gastroenterology（2022）

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摘要

PegIFN combined TDF followed by protocolized TDF withdrawal led to earlier but not higher percentages of HBsAg clearance. Pre-treatment HBeAg positivity and subgenotype A2 were strongly associated with HBsAg clearance.

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关键词

HBeAg, genotype, quantitative HBsAg, flare, discontinuation

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