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PM 2.5 induce lifespan reduction, insulin/IGF-1 signaling pathway disruption and lipid metabolism disorder in Caenorhabditis elegans .

Wenjing Zhang,Zinan Li,Guojun Li,Ling Kong,Haiming Jing,Nan Zhang,Junyu Ning,Shan Gao, Yong Zhang,Xinyu Wang,Jing Tao

Frontiers in public health（2023）

Cited 3|Views40
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Abstract
WS-PM exposure induce varying degrees of toxic effects, such as body development, shorten lifespan and healthspan. The IIS pathway and lipid metabolism/transport were disturbed by WS-PM during WS-PM exposure, suggesting their regulatory role in lifespan determination.
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Key words
Caenorhabditis elegans,PM2.5,RNA-Sequencing,gene homology,healthspan,lifespan
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