Intratumoral STING activation causes durable immunogenic tumor eradication in the KP soft tissue sarcoma model.

Kayla L Marritt,Karys M Hildebrand,Kurt N Hildebrand,Arvind K Singla,Franz J Zemp,Douglas J Mahoney,Frank R Jirik,Michael J Monument

Frontiers in immunology（2022）

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摘要

These data suggest intratumoral activation of the STING pathway elicits local and systemic anti-tumor immune responses in a lymphocyte poor sarcoma model and deserves further evaluation as an adjunctive local and systemic treatment for sarcomas.

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关键词

KP sarcoma model,cGAS/STING,cancer immunotherapy,soft tissue sarcoma,undifferentiated pleomorphic sarcoma

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