A Multivalent and Thermostable Nanobody Neutralizing SARS-CoV-2 Omicron (B.1.1.529).

Yuying Lu,Qianlin Li,Huahao Fan,Conghui Liao, Jingsong Zhang,Huan Hu,Huaimin Yi,Yuanli Peng,Jiahai Lu,Zeliang Chen

International journal of nanomedicine（2023）

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摘要

Our study indicated that the AaLS could be used as an antibody-binding nanoplatform to present nanobodies on its surface and improve the potency of nanobodies. The multivalent nanobody LS-B-B2 may serve as a potential agent for the neutralization of SARS-CoV-2 variants.

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关键词

COVID-19,bio-nanotechnology,nanobody multimers,self-assembly,thermal stability

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