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Obinutuzumab Effectively Depletes Key B-cell Subsets in Blood and Tissue in End-stage Renal Disease Patients.

Cary M Looney,Aaron Schroeder,Erica Tavares,Jay Garg,Thomas Schindler,Flavio Vincenti,Robert R Redfield,Stanley C Jordan,Stephan Busque,E Steve Woodle,Jared Khan,Jeffrey Eastham, Sandrine Micallef,Cary D Austin,Alyssa Morimoto

Transplantation direct（2023）

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Abstract
Our data further characterize the mechanistic profile of obinutuzumab and suggest that it may elicit greater efficacy in indications such as lupus where B-cell targeting therapeutics are limited by the resistance of pathogenic tissue B cells to depletion.
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Key words
b-cell,end-stage
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