An HPA-1a-positive platelet-depleting agent for prevention of fetal and neonatal alloimmune thrombocytopenia: a randomized, single-blind, placebo-controlled, single-center, phase 1/2 proof-of-concept study.

Christof Geisen,Mette Kjaer, Erika Fleck,Bjorn Skogen,Róisín Armstrong, Frank Behrens, Zubin Bhagwagar, Susanne Braeuninger,Anette Mortberg, Klaus Juel Olsen, Stephan Martin Gastón Schäfer, Carmen Walter,Erhard Seifried,Agneta Wikman,Jens Kjeldsen-Kragh,Michaela Koehm

Journal of thrombosis and haemostasis : JTH（2023）

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摘要

These data support the hypothesis that anti-HPA-1a could be used as prophylaxis in women at risk of having an FNAIT-affected pregnancy.

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关键词

alloantibodies,human platelet antigen,intracranial hemorrhage,neonatal alloimmune thrombocytopenia,prophylaxis

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