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Lipid Alteration Signature in the Blood Plasma of Individuals With Schizophrenia, Depression, and Bipolar Disorder.

Anna Tkachev,Elena Stekolshchikova,Anna Vanyushkina,Hanping Zhang,Anna Morozova,Svetlana Zozulya,Ilia Kurochkin,Nickolay Anikanov,Alina Egorova,Ekaterina Yushina,Thomas Vogl,Fanny Senner,Sabrina K Schaupp,Daniela Reich-Erkelenz,Sergi Papiol,Mojtaba Oraki Kohshour,Farahnaz Klöhn-Saghatolislam,Janos L Kalman,Urs Heilbronner,Maria Heilbronner,Katrin Gade,Ashley L Comes,Monika Budde,Heike Anderson-Schmidt,Kristina Adorjan,Jens Wiltfang,Eva Z Reininghaus,Georg Juckel,Udo Dannlowski,Andreas Fallgatter,Carsten Spitzer,Max Schmauß,Martin von Hagen,Yana Zorkina,Alexander Reznik,Aleksandra Barkhatova,Roman Lisov,Nikita Mokrov,Maxim Panov,Dmitri Zubkov,Daria Petrova,Chanjuan Zhou,Yiyun Liu,Juncai Pu,Peter Falkai,Georgiy Kostyuk,Tatiana Klyushnik,Thomas G Schulze,Peng Xie,Eva C Schulte,Philipp Khaitovich

JAMA psychiatry（2023）

Cited 5|Views59
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Abstract
In this study, SCZ was accompanied by a reproducible profile of plasma lipidome alterations, not associated with symptom severity, medication, and demographic and environmental variables, and largely shared with BPD and MDD. This lipid alteration signature may represent a trait marker of severe psychiatric disorders, indicating its potential to be transformed into a clinically applicable testing procedure.
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Key words
lipid alteration signature,schizophrenia,blood plasma
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