PERK-STING-RIPK3 pathway facilitates cognitive impairment by inducing neuronal necroptosis in sepsis-associated encephalopathy.

Guo Xiaofeng,Wu You,Jia Qi,Ma Hongwei,Fan Zhongmin,Wang Shiquan,Du Lixia,Peng Yuliang,Fang Zongping,Zhang Xijing

CNS neuroscience & therapeutics（2023）

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摘要

PERK-STING-RIPK3 pathway facilitates cognitive impairment by inducing neuronal necroptosis in the pathology of SAE, which provided a new therapeutic target in SAE treatment.

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关键词

PERK,RIPK3,STING,necroptosis,sepsis-associated encephalopathy

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