Clinical significance of concomitant bacteriuria in patients with Staphylococcus aureus bacteraemia

This retrospective study, conducted at Lausanne University Hospital (2015–2021), compared Staphylococcus aureus bacteraemia (SABA) patients with or without concomitant bacteriuria (SABU). Among 448 included bacteraemic patients, 62 (13.8%) had S. aureus concurrently isolated from urine. In multivariate analysis, there was a significant difference in the odds of community-onset bacteraemia ( P 0.030), malignancy ( P 0.002), > 1 pair of positive blood cultures ( P 0.037), and persistent bacteraemia for at least 48 h ( P 0.045) in patients with concurrent SABU. No difference concerning mortality was found. On the other hand, SABU was associated with higher rates of SABA recurrence after antibiotic cessation.