Autolysosomal activation combined with lysosomal destabilization efficiently targets myeloid leukemia cells for cell death.
Frontiers in oncology(2023)
摘要
In conclusion, mefloquine treatment combined with mTOR inhibition synergistically induced targeted ML cell death without additional toxicity. Taken together, these data provide a molecular mechanism and thus a rationale for a therapeutic approach for specific targeting of ML lysosomes.
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关键词
cancer treatment,lysosomal cell death,lysosomal membrane permeabilization,mefloquine and autophagy,myeloid leukemia
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