House Dust Mite and Cat Dander Extract Induce Asthma-Like Histopathology with an Increase of Mucosal Mast Cells in a Guinea Pig Model.

Patricia Ramos-Ramírez,Jielu Liu,Sofia Mogren,Joshua Gregory,Malin Noreby,Anne Petrén,Ying Lei,Henric Olsson,Marianne van Hage,Jukka Kervinen,Lars Hellman,Cecilia Andersson,Gunnar Nilsson,Mikael Adner

Journal of immunology research（2023）

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Abstract

We here show that exposure to HDM and CDE elicits asthma-like histopathology in guinea pigs with infiltration of inflammatory cells, airway remodelling, and accumulation of primarily mucosal mast cells. The results together encourage the use of HDM and CDE allergens for the stimulation of a clinically relevant asthma model in guinea pigs.

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Key words

house dust mite,mucosal mast cells,asthma-like

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