Effect on micellization behavior of promethazine hydrochloride and dimethyldodecylethylammonium bromide mixture in distinctive media: A multi-technique study

Herein, we studied the impact of cationic surfactant dimethyldodecylethylammonium bromide (DMDEABr) on the micellization of promethazine hydrochloride (PMH) through different methods: surface tensions, UV, and FT-IR. DMDEABr surfactant behaves synergistically with PMH in all media (H2O, 50 mmol.kg(-1) NaCl, and 200 mmol.kg(-1) fructose). The accomplished outcomes of critical micelles concentration (cmc) of PMH + DMDEABr from the tensiometry method observed significant deviation from their comparable ideal value (cmc(id)) which unveiled the nonideal behavior of PMH + DMDEABr mixture. When fructose is added to solutions of PMH, DMDEABr, and PMH + DMDEABr, cmc increases as well as decreases depending on the concentration of fructose. Here, the concentration of fructose employed decreases cmc value, whereas added NaCl decreases cmc value more. DMDEABr is found to have a higher micellar composition in mixed micelles than PMH except at the lowest employed mole fraction (alpha(1)) of DMDEABr. Interaction parameters (mixed micellar/mixed interface) demonstrated the attractive/synergism amongst PMH and DMDEABr. Numerous thermodynamic parameter evaluations showed that mixed systems are both spontaneous and stable. PMH's absorption intensity increased due to DMDEABr's interaction with PMH as observed by UV-visible spectra. In addition to identifying peak shifting in spectra of PMH (pure component), FT-IR analyses confirmed that PMH and DMDEABr were interacting with each other. Drug delivery across membranes can be greatly enhanced when mixed micelles form since they increase solubility and permeability. (C) 2023 Elsevier B.V. All rights reserved.