Evidence of cerebral hypoperfusion consecutive to ultrasound-mediated blood-brain barrier opening in rats.

Magnetic resonance in medicine(2023)

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摘要
This study provided strong evidence that BBB opening using microbubble intravenous injection induces a transient hypoperfusion. A spatiotemporal analysis of the hypoperfusion changes allows to establish some points of similarity with the cortical spreading depression phenomenon.
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关键词
DSC,MRI,blood brain barrier opening,brain perfusion,pCASL,rodent,ultrasound
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