Leucine mediates cognitive dysfunction in early life stress-induced mental disorders by activating autophagy.
Frontiers in cellular neuroscience（2022）
Abstract
MS model caused adult male rats to be susceptible to cognitive dysfunction, which may regulate autophagy in hippocampal neurons through leucine metabolism in CSF.
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Key words
autophagy,cerebrospinal fluid,cognitive impairment,leucine,maternal separation stress,mental disorders
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