Prognostic value of tumor mutation burden in patients with advanced gastric cancer receiving first-line chemotherapy.
Frontiers in oncology(2022)
Abstract
TMB-high advanced gastric cancer patients accounted for around one-sixth and had a poorer prognosis than TMB-low patients when treated with first-line chemotherapy. The potential mechanism might be the downregulated metabolic activity in TMB-high patients.
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Key words
biomarker,chemotherapy,gastric cancer,mechanism,prognostic value,tumor mutation burden
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