Dorsal raphe serotonergic neurons suppress feeding through redundant forebrain circuits

Iltan Aklan, Nilufer Sayar-Atasoy,Fei Deng,Hyojin Kim,Yavuz Yavuz,Jacob Rysted,Connor Laule,Debbie Davis,Yulong Li,Deniz Atasoy

Molecular Metabolism（2023）

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摘要

•DRN5HT neurons suppress feeding through projections to LH and BNST.•5HT levels in LH respond to food and satiety hormones but not to the hunger hormone ghrelin.•5HT from DRN axons inhibit GABA release from AgRP presynaptic terminals onto LH neurons.•DRN axons activate and inhibit glutamatergic and GABAergic LH neurons respectively.

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关键词

Serotonin,5HT,Feeding,Dorsal raphe,Satiety

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