Posttraumatic Osteomyelitis Risks Associated with NLRP3 Gene Polymorphisms in the Chinese Population.

The purpose of this case-control study was to examine possible links between gene polymorphisms and the risk of developing posttraumatic osteomyelitis (PTOM) in the Chinese population. A total of 306 patients with PTOM and 368 normal controls were genotyped for (rs35829419, rs10754558, rs7525979, rs4612666), (rs1785929, rs1789547, rs1785928, rs12185396, rs681757, rs8299, rs2032206, rs559289), (rs4796793, rs744166, rs1026916, rs2293152, rs1053004), (rs501192, rs580253, rs556205, rs530537), NFKBIA (rs696), (rs4648068), (rs204321), and (rs2569190) using the genotyping technique SNaPshot. The genotype distributions of gene rs10754558 ( = 0.047) and rs7525979 ( = 0.048) significantly differed between the patients and the healthy controls. Additionally, heterozygous models indicated a significant association between rs10754558 and the likelihood of developing PTOM (OR = 1.600, = 0.039), as did recessive and homozygous models of rs7525979 (OR = 0.248, = 0.019 and 0.239, = 0.016, respectively). Collectively, our findings suggest that, in the Chinese population, the risk of developing PTOM was increased by the association between rs10754558 and rs7525979. Therefore, our findings may provide novel insights and guidance in the prevention and development of PTOM.