Meta-analysis of the clinical efficacy of Liqi Huoxue drop pill in the treatment of angina pectoris in coronary artery disease

Objective: To evaluate the efficacy of Liqi Huoxue dropping pills in the treatment of angina pectoris in coronary heart disease using the Meta-analysis system. Methods: Randomized controlled trials (RCT) on the treatment of angina pectoris in coronary artery disease with the combination of Western medicine with Liqi Huoxue drop pills were searched using computerized search databases, including English databases PubMed, Embase, Web of Science, The Cochrane Library and Chinese databases CNKI, VIP, WanFang Data and CBM from the time of establishment until February 1, 2022. Data extraction was performed independently by two investigators and the quality of the literature of the included studies was assessed. A meta-analysis of the included literature was performed using Revman 5.4 software. Results: Nine studies with a total of 982 patients were included. The results of Meta-analysis showed that the observation group, which adopted conventional treatment of Western medicine combined with Li qi huo xue dropping pills, was better than the control group, which was treated with conventional Western medicine alone. Clinical efficacy of the intervention group[R R=1.20,95％CI=(1.12,1.29),P<0.00001],Angina pectoris symptom treatment[RR=1.17,95％CI =(1.07,1.29),P=0.0010],Number of angina attacks [SMD=-2.26,95％CI(-4.10,-0.42),P=0.002],IL-6[MD=-4.65,95％CI(-6.91,-2.39),P<0.0001],IL-18[MD=-2.53,95％CI(-2.84,-2.22),P<0.00001],HS-CRP[MD=-0.08,95％CI(-1.81,-0.75),P<0.00001],and NO[M D=8.03,95％CI(0.93,15.14),P=0.03] were significantly different and better than the control group (western conventional treatment), and the differences were all statistically significant. Conclusion: Combining Liqi Huoxue drop pill with conventional Western medicine for patients with coronary angina can effectively improve the clinical efficacy, the efficacy of angina symptoms, the number of angina attacks, serum inflammatory indexes interleukin-6, interleukin-18, high-sensitivity C-reactive protein, and endothelial function NO indexes in patients with coronary angina, providing a reliable evidence-based basis for combining Liqi Huoxue drop pill with Western medicine for the treatment of coronary angina.