In Reply to Elmali and Yazici.

We are grateful for the comments regarding our article, 1 Trofimov AV, Aronow ME, Gragoudas ES, et al. A systematic comparison of dose distributions delivered in 125I plaque brachytherapy and proton radiation therapy for ocular melanoma [e-pub ahead of print]. Int J Radiat Oncol Biol Phys. https://doi.org/10.1016/j.ijrobp.2022.07.017, accessed November 11, 2022. Google Scholar which describes dose comparison between 125I plaque brachytherapy and proton therapy for ocular melanoma. Other forms of external beam radiation are used less frequently in treatment of this disease. Megavoltage γ- or x-ray experience spans more than 3 decades, from Gamma Knife 2 Logani S Helenowski TK Thakrar H Pothiawala B. Gamma knife radiosurgery in the treatment of ocular melanoma. Stereotact Funct Neurosurg. 1993; 61: 38-44 Crossref PubMed Scopus (21) Google Scholar to linear accelerator-based techniques, 3 Dunavoelgyi R Zehetmayer M Gleiss A et al. Hypofractionated stereotactic photon radiotherapy of posteriorly located choroidal melanoma with five fractions at ten Gy—clinical results after six years of experience. Radiother Oncol. 2013; 108: 342-347 Abstract Full Text Full Text PDF PubMed Scopus (20) Google Scholar which continue to evolve. 4 Ciernik IF Wösle M Krause L Krayenbuehl J. Optimizing radiosurgery with photons for ocular melanoma. Phys Imaging Radiat Oncol. 2018; 6: 83-88 Abstract Full Text Full Text PDF Scopus (6) Google Scholar