Reprogramming of IL-12 secretion in the PDCD1 locus improves the anti-tumor activity of NY-ESO-1 TCR-T cells.

Segi Kim, Cho I Park,Sunhwa Lee,Hyeong Ryeol Choi,Chan Hyuk Kim

Frontiers in immunology（2023）

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摘要

Our approach may provide a way to safely harness the therapeutic potential of potent immunostimulatory cytokines for the development of effective adoptive T cell therapies against solid tumors.

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关键词

CRISPR/Cas9,NY-ESO-1,PD-1,TCR-T,immunotherapy,interleukin-12

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