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Novel method to quantify peptidylarginine deiminase activity shows distinct citrullination patterns in rheumatoid and juvenile idiopathic arthritis.

Karen Yu,Luna Dillemans,Mieke Gouwy, Helena Bessa,Mieke Metzemaekers,Erik Martens,Patrick Matthys,Xavier Bossuyt,Patrick Verschueren,Carine Wouters,Lien De Somer,Paul Proost

Frontiers in immunology（2023）

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Abstract
Our finding suggests that enhanced synovial PAD activity drives the loss in tolerance towards citrullinated proteins and that systemic citrullination may indicate the risk for developing citrulline-specific autoimmunity.
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Key words
autoimmunity,citrullination,inflammation,joint inflammation,peptidylarginine deiminase
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