In silico targeting of lipoxygenase, CYP2C9, and NAD(P)H oxidase by major green tea polyphenols to subvert oxidative stress

Prem Rajak,Abhratanu Ganguly,Moutushi Mandi,Anik Dutta,Saurabh Sarkar,Sayantani Nanda,Kanchana Das,Siddhartha Ghanty,Gopal Biswas

Advances in Redox Research（2023）

引用 2|浏览1

暂无评分

摘要

•ROS-mediated oxidative stress (OS) induces several life-threatening diseases.•Lipoxygenase, CYP2C9, and NAD(P)H oxidase are producers of ROS.•Green tea polyphenols target these enzymes at ligand-binding pockets.•Binding is favored by H-bonds, van der waals, and alkyl/pi-alkyl interactions.•Binding with ROS producers could subvert OS and subsequent health hazards.

查看译文

关键词

Green tea,Catechins,Oxidative stress,Lipoxygenase,CYP2C9,NAD(P)H oxidase

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要