LY6E protects mice from pathogenic effects of murine coronavirus and SARS-CoV-2.

Katrina B Mar,Marley C Van Dyke,Alexandra H Lopez,Jennifer L Eitson,Wenchun Fan,Natasha W Hanners,Bret M Evers,John M Shelton,John W Schoggins

biorxiv（2023）

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摘要

LY6E is an antiviral protein that inhibits coronavirus entry. Its expression in immune cells allows mice to control murine coronavirus infection. However, it is not known which immune cell subsets mediate this control or whether LY6E protects mice from SARS-CoV-2. In this study, we used tissue-specific Cre recombinase expression to ablate Ly6eLy6eLyz2Vav1Ly6eLy6eMuc5b

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murine coronavirus,pathogenic effects,mice,sars-cov

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