The contribution of the alternative pathway in complement activation on cell surfaces depends on the strength of classical pathway initiation.

Esther CW deBoer,Astrid JF Thielen,Jeroen D Langereis,Angela Kamp,Mieke C Brouwer,Nienke Oskam,Marlieke L Jongsma,April J Baral,Robbert M Spaapen, Sacha Zeerleder,Gestur Vidarsson,Theo Rispens,Diana Wouters,Richard B Pouw,Ilse Jongerius

Clinical & translational immunology（2023）

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摘要

The AP can be bypassed through efficient CP activation. The AP amplification loop has a role in complement activation during conditions of modest activation via the CP, when it can allow for efficient complement-mediated killing.

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关键词

alternative pathway,amplification loop,antibodies,autoimmune haemolytic anaemia,classical pathway,complement activation

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