Regulation of Photosensitivity by the Hippo Pathway in Lupus Skin.

Grace A Hile,Patrick Coit,Bin Xu,Amanda M Victory,Mehrnaz Gharaee-Kermani,Shannon N Estadt,Mitra P Maz,Jacob W S Martens,Rachael Wasikowski,Craig Dobry,Lam C Tsoi,Ramiro Iglesias-Bartolome,Celine C Berthier,Allison C Billi,Johann E Gudjonsson,Amr H Sawalha,J Michelle Kahlenberg

Arthritis & Rheumatology（2023）

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摘要

Our work unravels a novel driver of photosensitivity in SLE: overactive Hippo signaling in SLE keratinocytes restricts YAP transcriptional activity, leading to shifts that promote UVB apoptosis.

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关键词

hippo pathway,lupus,photosensitivity

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