Structural rationalization of GSPT1 and IKZF1 degradation by thalidomide molecular glue derivatives
RSC Medicinal Chemistry(2023)
Abstract
Thalidomide and its derivatives are molecular glues that bind cereblon (CRBN), a component of an E3 ubiquitin ligase complex, and mediate protein interactions with neosubstrates resulting in their polyubiquitination and...
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Key words
molecular glue derivatives,ikzf1 degradation,gspt1
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