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Structural rationalization of GSPT1 and IKZF1 degradation by thalidomide molecular glue derivatives

Radosław P. Nowak,Jianwei Che,Silas Ferrao,Nikki R. Kong,Hu Liu,Breanna L. Zerfas,Lyn H Jones

RSC Medicinal Chemistry（2023）

Cited 3|Views25
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Abstract
Thalidomide and its derivatives are molecular glues that bind cereblon (CRBN), a component of an E3 ubiquitin ligase complex, and mediate protein interactions with neosubstrates resulting in their polyubiquitination and...
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Key words
molecular glue derivatives,ikzf1 degradation,gspt1
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