New Methylcitrate Synthase Inhibitor Induces Proteolysis, Lipid Degradation and Pyruvate Excretion in Paracoccidioides brasiliensis .

Olivia Basso Rocha,Kleber Santiago Freitas E Silva,Thaynara Gonzaga Santos,Dayane Moraes,Leandro do Prado Assunção,Alexandre Melo Bailão,Célia Maria de Almeida Soares,Maristela Pereira

Journal of fungi (Basel, Switzerland)（2023）

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摘要

The inhibition of methylcitrate synthase caused by the compound promoted a metabolic shift in damaging energy production and generating oxidative stress. Hence, the compound is a promising alternative for developing new strategies of therapies against paracoccidioidomycosis.

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关键词

antifungal,methylcitrate cycle,methylcitrate synthase,paracoccidiodomycosis

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